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Richard L Proia Selected Research

Sphingosine-1-Phosphate Receptors

1/2021Endothelial S1P1 Signaling Counteracts Infarct Expansion in Ischemic Stroke.
11/2019Murine platelet production is suppressed by S1P release in the hematopoietic niche, not facilitated by blood S1P sensing.
4/2015Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy.
1/2015Activated platelets release sphingosine 1-phosphate and induce hypersensitivity to noxious heat stimuli in vivo.
2/2013Sphingosine-1-phosphate-induced nociceptor excitation and ongoing pain behavior in mice and humans is largely mediated by S1P3 receptor.
11/2012A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis.
6/2011The sphingosine 1-phosphate receptor S1P₂ maintains the homeostasis of germinal center B cells and promotes niche confinement.
3/2011Sphingosine-1-phosphate lyase deficiency produces a pro-inflammatory response while impairing neutrophil trafficking.
5/2010Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice.
8/2008Sphingosine kinase 1/S1P receptor signaling axis controls glial proliferation in mice with Sandhoff disease.
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Richard L Proia Research Topics

Disease

7Inflammation (Inflammations)
01/2020 - 05/2002
5Neurodegenerative Diseases (Neurodegenerative Disease)
01/2021 - 12/2004
4Insulin Resistance
01/2018 - 03/2003
3Atherosclerosis
12/2019 - 08/2015
3Anaphylaxis (Anaphylactic Shock)
04/2018 - 03/2007
3Sandhoff Disease (Sandhoff's Disease)
01/2018 - 06/2004
3Neoplasms (Cancer)
11/2017 - 10/2002
3Multiple Sclerosis
01/2016 - 05/2011
2Brain Injuries (Brain Injury)
01/2021 - 05/2014
2Thrombocytopenia (Thrombopenia)
11/2019 - 11/2012
2Hemorrhage
11/2019 - 12/2005
2GM2 Gangliosidoses (GM2 Gangliosidosis)
01/2018 - 06/2016
2Vascular Diseases (Vascular Disease)
08/2015 - 10/2004
2Neuroinflammatory Diseases
07/2015 - 04/2015
2Hypoxia (Hypoxemia)
03/2015 - 04/2004
2Gliosis
05/2011 - 08/2008
1Ischemic Stroke
01/2021
1Sphingolipidoses (Sphingolipidosis)
01/2021
1Hemorrhagic Stroke
01/2021
1Congenital, Hereditary, and Neonatal Diseases and Abnormalities (Congenital Disorders)
03/2020
1Nervous System Malformations (Nervous System Congenital Malformations)
03/2020
1Ischemia
01/2020
1Coronary Disease (Coronary Heart Disease)
12/2019
1GM1 Gangliosidosis (Gangliosidosis GM1)
12/2019
1Thrombosis (Thrombus)
11/2019
1Macular Degeneration (Age-Related Maculopathy)
10/2019
1Inborn Genetic Diseases (Disease, Hereditary)
01/2019
1Lymphoma (Lymphomas)
11/2017
1Fatty Liver
01/2017
1Gangliosidoses (Gangliosidosis)
06/2016
1Alzheimer Disease (Alzheimer's Disease)
01/2016
1Hypersensitivity (Allergy)
01/2015
1Mitochondrial Diseases (Mitochondrial Disease)
05/2014
1Wounds and Injuries (Trauma)
05/2014
1Traumatic Brain Injuries (Traumatic Brain Injury)
05/2014
1Asthma (Bronchial Asthma)
11/2013
1Pain (Aches)
02/2013
1Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse)
06/2011
1Demyelinating Diseases (Demyelinating Disease)
05/2011
1Acute-Phase Reaction
03/2011
1Metabolic Diseases (Metabolic Disease)
04/2010
1Osteoporosis
03/2009
1Reperfusion Injury
02/2009
1Spontaneous Abortion (Miscarriage)
10/2007
1Pathologic Neovascularization
09/2007
1Autoimmune Diseases (Autoimmune Disease)
05/2007
1Deafness (Deaf Mutism)
04/2007
1Paralysis (Palsy)
01/2007
1Adenoma (Adenomas)
10/2006

Drug/Important Bio-Agent (IBA)

13Sphingosine-1-Phosphate ReceptorsIBA
01/2021 - 04/2004
7SphingosineIBA
12/2019 - 12/2004
7sphingosine kinaseIBA
11/2019 - 08/2006
6Fingolimod Hydrochloride (FTY720)FDA Link
01/2021 - 12/2004
6SphingolipidsIBA
01/2021 - 10/2007
6LipidsIBA
12/2019 - 04/2010
6sphingosine 1-phosphate (sphingosine-1-phosphate)IBA
11/2019 - 01/2015
5EnzymesIBA
01/2021 - 05/2002
3Proteins (Proteins, Gene)FDA Link
03/2020 - 12/2004
3Phosphotransferases (Kinase)IBA
05/2010 - 08/2006
2GlycosphingolipidsIBA
01/2019 - 12/2005
2CeramidesIBA
01/2019 - 12/2014
2Immunoglobulin E (IgE)IBA
04/2018 - 11/2013
2GangliosidesIBA
06/2016 - 10/2002
2CytokinesIBA
11/2014 - 03/2011
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
12/2005 - 01/2005
1Complement System Proteins (Complement)IBA
03/2020
1Complement Inactivating AgentsIBA
03/2020
1LigandsIBA
01/2020
1Vasoconstrictor AgentsIBA
01/2020
1Glucocorticoid Receptors (Glucocorticoid Receptor)IBA
01/2020
1CholesterolIBA
12/2019
1GalactosidasesIBA
12/2019
1G(M1) GangliosideIBA
12/2019
1oxidized low density lipoproteinIBA
08/2018
1LDL Receptors (LDL Receptor)IBA
08/2018
1anti-IgE antibodiesIBA
04/2018
1IgE Receptors (Fc epsilon RI)IBA
04/2018
1G(M2) Ganglioside (Ganglioside GM2)IBA
01/2018
1Hexosaminidase A (Hex A)IBA
01/2018
1Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA
01/2018
1Cell Surface ReceptorsIBA
11/2017
1G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
11/2017
1Blood Glucose (Blood Sugar)IBA
01/2017
1Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA
08/2015
1Apolipoproteins E (ApoE)IBA
08/2015
1TRPC6 Cation ChannelIBA
03/2015
1Interleukin-6 (Interleukin 6)IBA
11/2014
1Electron Transport Complex IV (Cytochrome c Oxidase)IBA
05/2014
1Neutral CeramidaseIBA
05/2014
1GTP-Binding Proteins (G-Protein)IBA
02/2013
1CuprizoneIBA
05/2011
1LyasesIBA
03/2011
1Histamine (Histamine Dihydrochloride)FDA Link
05/2010
1ErythropoietinFDA Link
02/2009
1erucylphosphocholineIBA
02/2009
1Botulinum Toxins (Botulinum Toxin)IBA
01/2007

Therapy/Procedure

2Therapeutics
11/2017 - 06/2016
1Tissue Expansion
01/2018
1Injections
01/2015
1Ovariectomy (Oophorectomy)
03/2009